FLOW-MEDIATED DILATATION IDENTIFIES IMPAIRED ENDOTHELIAL FUNCTION IN PATIENTS WITH SLEEP APNEA SYNDROME

• YOSHIHISA AKIOMI

  Department of Cardiology and Hematology, Fukushima Medical University

• OWADA TAKASHI

  Department of Cardiology and Hematology, Fukushima Medical University

• HOSHINO YASUTO

  Department of Cardiology and Hematology, Fukushima Medical University

• MIYATA MAKIKO

  Department of Cardiology and Hematology, Fukushima Medical University

• MISAKA TOMOFUMI

  Department of Cardiology and Hematology, Fukushima Medical University

• SATO TAKAMASA

  Department of Cardiology and Hematology, Fukushima Medical University

• SUZUKI SATOSHI

  Department of Cardiology and Hematology, Fukushima Medical University

• SAKAMOTO NOBUO

  Department of Cardiology and Hematology, Fukushima Medical University

• SUGIMOTO KOICHI

  Department of Cardiology and Hematology, Fukushima Medical University

• KUNII HIROYUKI

  Department of Cardiology and Hematology, Fukushima Medical University

• NAKAZATO KAZUHIKO

  Department of Cardiology and Hematology, Fukushima Medical University

• SUZUKI HITOSHI

  Department of Cardiology and Hematology, Fukushima Medical University

• SAITOH SHU-ICHI

  Department of Cardiology and Hematology, Fukushima Medical University

• ISHIBASHI TOSHIYUKI

  Department of Cardiology and Hematology, Fukushima Medical University

• TAKEISHI YASUCHIKA

  Department of Cardiology and Hematology, Fukushima Medical University

抄録

[Background] Non-invasive detection of vascular dysfunction in the early stage is clinically important in patients with sleep apnea syndrome (SAS). Flow-mediated dilatation (FMD) is a novel clinical marker of endothelial function. However, it is not clear whether this is useful in the SAS patient. [Methods] Echocardiographic parameters and FMD were measured in 129 patients with SAS. Apnea-hypopnea index (AHI) was defined by polygraphy, and patients were divided into the two Groups: Group A (moderate-severe SAS: AHI≥ 15 times/hr, n=93) and Group B (mild SAS: AHI 5-15 times/hr, n=36). [Results] There were no significant differences in echocardiographic parameters between the two groups. However, FMD was significantly lower in Group A than in Group B (3.5±1.6 vs. 7.8±3.1, P< 0.01). [Conclusions] Although cardiac function was not different, vascular dysfunction was evident in patients with moderate-severe SAS. FMD is a useful tool to identify impaired endothelial function non-invasively in patients with SAS.

収録刊行物

• 福島医学会

  福島医学会 56 (2), 115-120, 2010

  福島医学会

キーワード

• sleep apnea syndrome
• vascular function
• endothelial function
• flow-mediated dilatation

詳細情報

• CRID: 1390001206305325056
• NII論文ID: 130000419018
• NII書誌ID: AA0065246X
• DOI: 10.5387/fms.56.115
• ISSN: 21854610
• ISSN: 00162590
• Web Site: http://ir.fmu.ac.jp/dspace/handle/123456789/269
• Web Site: https://search.jamas.or.jp/link/ui/2012213119
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可