Patient-specific Morphological and Blood Flow Analysis of Pulmonary Artery in the Case of Severe Deformations of the Lung due to Pneumothorax
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- CHRISTOPHE Jean-Joseph
- Department of Biomedical engineering, Tohoku University Department of Applied Mathematics, Paris VI University
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- ISHIKAWA Takuji
- Department of Bioengineering and Robotics, Tohoku University
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- MATSUKI Noriaki
- Department of Biomedical engineering, Tohoku University
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- IMAI Yohsuke
- Department of Bioengineering and Robotics, Tohoku University
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- TAKASE Kei
- Department of Radiology, Tohoku University
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- THIRIET Marc
- Department of Applied Mathematics, Paris VI University
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- YAMAGUCHI Takami
- Department of Biomedical engineering, Tohoku University
Abstract
Pneumothorax is characterized by lung collapse. Its effect on hemodynamics, especially on pulmonary arterial blood flow, remains unclear. This patient-specific study investigated the effects of lung deformation on pulmonary blood flow during acute phase and after recovery. Arterial geometry was extracted up to the fifth generation from computed tomography images in three patients and reconstructed. Different geometrical parameters (artery bores, area ratios, and between-branch angles) were computed. The shapes of the pulmonary trunk and its branches were affected strongly by pneumothorax. To clarify the effect of geometrical perturbations on blood flow, the Navier—Stokes equations for a steady laminar flow of Newtonian incompressible fluid were solved in a reconstructed domain. The change in flow structure between acute phase and recovery was associated with variations in flow rate ratio between the right and left lungs. This study shows, possibly for the first time, that from a patient-specific numerical test, pneumothorax has a considerable impact on pulmonary arterial morphology and hemodynamics.
Journal
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- Journal of Biomechanical Science and Engineering
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Journal of Biomechanical Science and Engineering 5 (5), 485-498, 2010
The Japan Society of Mechanical Engineers
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Keywords
Details 詳細情報について
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- CRID
- 1390001205261724032
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- NII Article ID
- 130000422532
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- ISSN
- 18809863
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed