Predicting Interactions between Medicinal Drugs and New Supplements

• KUBOTA Takahiro

  Pharmacentical Department of Scientific Research, Graduate School of Pharmacential Sciences,Chiba Institute of Science

• YOSHIOKA Shin’ichi

  Food Analysis Services Department, SRL, Inc.

• KAWAGOE Nobuhide

  Food Analysis Services Department, SRL, Inc.

• TOYODA Tsuyoshi

  Biotherapy Development Research Center Co. Ltd.

• ISHIBASHI Norihito

  Biotherapy Development Research Center Co. Ltd.

• SUZUKI Nobutaka

  Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University

Bibliographic Information

Other Title

• 新規サプリメントと医薬品の相互作用を予見する
• シンキ サプリメント ト イヤクヒン ノ ソウゴ サヨウ オ ヨケンスル

Abstract

Information regarding drug interactions is useful for avoiding adverse effects from medicinal drug administration, and similar information is obviously desirable for health food products and supplements. When examining findings related to drug-supplement interactions, it is vital to understand pharmacokinetics such as drug absorption, distribution, metabolism, and excretion. The interaction disposition of one particular drug is primarily related to inhibition and induction of the drug-metabolizing enzyme cytochrome P450 (CYP). Thus, experiments evaluating the expression level of CYP isoforms in human hepatic microsomes and their relative ratio in drugs metabolized by them would be useful. However, investigations of drug-supplement interactions such as inhibition tests using the cDNA-expressed human CYP and specific substrates in combination are scarce. It is essential to consider studies for averting such interactions and to disseminate information for improving safety.<br>

Journal

• Japanese Journal of Complementary and Alternative Medicine

  Japanese Journal of Complementary and Alternative Medicine 7 (2), 67-74, 2010

  The Japanese Society for Complementary and Alternative Medicine

Keywords

• adverse effects
• health food products
• supplements
• drug-supplement interactions
• cytochrome P450
• CYP

Details

• CRID: 1390282680195793408
• NII Article ID: 130000422871
• NII Book ID: AA12095429
• DOI: 10.1625/jcam.7.67
• ISSN: 13487930
• ISSN: 13487922
• NDL BIB ID: 10856479
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10856479
• Web Site: https://www.jstage.jst.go.jp/article/jcam/7/2/7_2_67/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011035614
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed