A Polymorphism Observed in the Experimentally Successful Peptide Vaccine Sequence Derived from Theileria sergenti Piroplasm Major Surface Antigen (p33).
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- KAWAZU Shin-Ichiro
- National Institute of Animal Health
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- OKUMURA Toshinari
- Abashiri Livestock Hygiene Service Center
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- HIROGARI Yasuhiro
- National Institute of Animal Health
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- MIYAHARA Tokuji
- The Chemo-Sero-Therapeutic Research Institute
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- TERASAKA Youichiro
- Kurayoshi Livestock Hygiene Service Center
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- HIDA Motonobu
- Ujiie Livestock Hygiene Service Center
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- TERADA Yutaka
- National Institute of Animal Health
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- KAMIO Tsugihiko
- National Institute of Animal Health
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- FUJISAKI Kozo
- Japan International Research Center for Agricultural Sciences
抄録
A polymorphism in the experimentally successful peptide vaccine sequence (EVVWKEKKEVKDLDA, amino acids 134-148) derived from the 33 kDa piroplasm major surface antigen (p33) of Theileria sergenti was examined. The vaccine sequences obtained by PCR amplification and sequencing of the p33 gene from a total of 15 parasite-infected cattle blood samples collected from 4 prefectures through Hokkaido to Kumamoto revealed the two major sequences (Ikeda and Chitose stock types) either of which was identified in all samples. Since the peptide vaccine develops the parasite species- or stock-specific immunity in the animals, an application of the two major peptide sequences as cocktailed vaccine should be evaluated for a practical use of this strategy to controlling T. sergenti infection in Japan.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 59 (9), 829-831, 1997
公益社団法人 日本獣医学会
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詳細情報
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- CRID
- 1390001206427176448
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- NII論文ID
- 130000437983
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- COI
- 1:CAS:528:DyaK2sXmvFGmsLY%3D
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- ISSN
- 13477439
- 09167250
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- PubMed
- 9342711
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可