Developmental Delay in Islet-1-Positive Motor Neurons in Chick Spina Bifida

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Author(s)

    • Wang Min WANG Min
    • Department of Anatomy and Embryology, Ehime University Graduate School of Medicine|Central Laboratory, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University
    • Mominoki Katsumi MOMINOKI Katsumi
    • Department of Biological Resources, Integrated Center for Science, Ehime University|Department of Animal Resources, Advanced Science Research Center, Okayama University
    • WANG Zhong
    • Department of Anatomy and Embryology, Ehime University Graduate School of Medicine|Central Laboratory, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University
    • SHIMOKAWA Tetsuya
    • Department of Anatomy and Embryology, Ehime University Graduate School of Medicine
    • NABEKA Hiroaki
    • Department of Anatomy and Embryology, Ehime University Graduate School of Medicine
    • FUJIWARA Takashi
    • Central Laboratory, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University
    • MATSUDA Seiji
    • Department of Anatomy and Embryology, Ehime University Graduate School of Medicine

Abstract

Spina bifida aperta (SBA) is a congenital malformation of the spinal cord with complications such as spinal ataxia and bowel and bladder dysfunction. We have developed a chick model with surgery-induced SBA that shows spinal ataxia after hatching. In the present study, motor neurons in the early stages in chicks with and without SBA were observed by immunohistochemical staining with a monoclonal antibody against Islet-1, a motor neuron marker. Delay in migration and maturation of motor neurons was observed in SBA. Although the final numbers of Islet-1-positive neurons in these two groups were not different, a defect in the production and elimination of excess motor neurons in the early developmental stages in the SBA group may be involved in the pathological mechanism of the motor complications of this disease.<br>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 73(4), 447-452, 2011

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130000444504
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • NDL Article ID
    11104734
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-350
  • Data Source
    NDL  J-STAGE 
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