Anatomy: Developmental delay in Islet-1-positive motor neurons in chick spina bifida
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- WANG Min
- Department of Anatomy and Embryology, Ehime University Graduate School of Medicine Central Laboratory, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University
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- MOMINOKI Katsumi
- Department of Biological Resources, Integrated Center for Science, Ehime University Department of Animal Resources, Advanced Science Research Center, Okayama University
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- KINUTANI Masae
- Department of Basic Health Science, School of Nursing, Ehime University
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- WANG Zhong
- Department of Anatomy and Embryology, Ehime University Graduate School of Medicine Central Laboratory, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University
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- KOBAYASHI Naoto
- Medical Education, Ehime University Graduate School of Medicine
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- SHIMOKAWA Tetsuya
- Department of Anatomy and Embryology, Ehime University Graduate School of Medicine
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- NABEKA Hiroaki
- Department of Anatomy and Embryology, Ehime University Graduate School of Medicine
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- FUJIWARA Takashi
- Central Laboratory, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University
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- MATSUDA Seiji
- Department of Anatomy and Embryology, Ehime University Graduate School of Medicine
書誌事項
- タイトル別名
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- Developmental Delay in Islet-1-Positive Motor Neurons in Chick Spina Bifida
- Chronological changes in Islet-1-positive neurons in a chick model of spina bifida aperta
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Spina bifida aperta (SBA) is a congenital malformation of the spinal cord with complications such as spinal ataxia and bowel and bladder dysfunction. We have developed a chick model with surgery-induced SBA that shows spinal ataxia after hatching. In the present study, motor neurons in the early stages in chicks with and without SBA were observed by immunohistochemical staining with a monoclonal antibody against Islet-1, a motor neuron marker. Delay in migration and maturation of motor neurons was observed in SBA. Although the final numbers of Islet-1-positive neurons in these two groups were not different, a defect in the production and elimination of excess motor neurons in the early developmental stages in the SBA group may be involved in the pathological mechanism of the motor complications of this disease.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 73 (4), 447-452, 2011
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681407929856
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- NII論文ID
- 130000444504
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 11104734
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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