Trans-Endothelial and Trans-Epithelial Transfer of Lactoferrin into the Brain through BBB and BCSFB in Adult Rats

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Author(s)

Abstract

The transportation of intravenously administered bovine lactoferrin (bLF) into the cerebrospinal fluid (CSF) was immunohistochemically investigated in adult rats. Administered bLF was detected in the vesicular membranes of endothelial cells in cerebral blood vessels 10 min after the infusion. Numerous immunoreactive small vesicles were also detected at the ependymal cells in the choroid plexus. Moreover, the bLF concentration in the CSF was significantly increased at 1-2 hr after the intravenous infusion of bLF (10 or 30 mg/kg). These findings clearly demonstrate that LF is possibly transported into the brain matter even in adult animals.<br>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 70(3), 313-315, 2008

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Cited by:  1

Codes

  • NII Article ID (NAID)
    130000447020
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0916-7250
  • Data Source
    CJPref  J-STAGE 
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