Clinicopathological Features of Canine Neuroaxonal Dystrophy and Cerebellar Cortical Abiotrophy in Papillon and Papillon-related Dogs
-
- NIBE Kazumi
- Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
-
- KITA Chiaki
- Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
-
- MOROZUMI Motoji
- Togasaki Animal Hospital
-
- AWAMURA Yuichi
- Totsuka Animal Hospital
-
- TAMURA Shinji
- Tamura Animal Hospital
-
- OKUNO Seiichi
- Animal Clinic Kobayashi
-
- KOBAYASHI Takayuki
- Animal Clinic Kobayashi
-
- UCHIDA Kazuyuki
- Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
Bibliographic Information
- Other Title
-
- パピオン犬およびパピオン関連犬種における神経軸索ジストロフィーと小脳皮質アビオトロフィーの臨床・病理所見
- Pathology: Clinicopathological features of canine neuroaxonal dystrophy and cerebellar cortical abiotrophy in papillon and papillon-related dogs
Search this article
Abstract
Neuroaxonal dystrophy (NAD) was examined in two Papillon dogs and a mix breed dog between Papillon and Chihuahua. In addition, cerebellar cortical abiotrophy (CCA) in a Papillon dog, which had similar clinical and magnetic resonance imaging (MRI) features to those of NAD, was also investigated. The common clinical symptoms of all dogs affected with NAD and CCA, were pelvic limb ataxia and cerebellar ataxia including intention tremor, head tremor, and hypermetria in the early onset. These clinical signs were progressed rapidly, and two dogs with NAD were euthanized by owner's request and the other two were died by aspiration pneumonia. MRI examinations and gross observations at necropsy revealed moderate to severe cerebellar atrophy in all cases of NAD and CCA. The most typical histological change of NAD was severe axonal degeneration with marked spheroid-formation in the dorsal horn of the spinal cords, the nuclei gracilis, cuneatus, olivalis and its circumference in the medulla oblongata. The spheroids were characterized as large eosinophilic or granular globes within the enlarged myelin sheaths, sometimes accompanied by moderate accumulation of microglias and/or macrophages. In contrast, such spheroid formation was minimal in the brain of CCA. In the cerebellum, mild to moderate loss of the Purkinje and granular cells were recognized in three dogs with NAD, whereas these changes were more prominent in a dog with CCA. Although the clinical signs and MRI findings relatively resembled between NAD and CCA, the histopathological features considered to be quite differ, suggesting distinct pathogenesis and etiology. Since both NAD and CCA are proposed as the autosomal recessive hereditary disorders, careful considerations might be needed for the breeding of Papillon and Chihuahua dogs.<br>
Journal
-
- Journal of Veterinary Medical Science
-
Journal of Veterinary Medical Science 69 (10), 1047-1052, 2007
JAPANESE SOCIETY OF VETERINARY SCIENCE
- Tweet
Details 詳細情報について
-
- CRID
- 1390001206427702528
-
- NII Article ID
- 130000447587
- 110006418724
-
- NII Book ID
- AA10796138
-
- ISSN
- 13477439
- 09167250
-
- NDL BIB ID
- 8985646
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed