Erythropoietin-Producing Cells in the Liver of ICR-Derived Glomerulonephritis (ICGN) Mice

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Author(s)

    • AKASHI Naotsugu
    • Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
    • GOTO Yasufumi
    • Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
    • ANAN Sayuri
    • Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo
    • YAMAMOTO Yoshie
    • Department of Veterinary Sciences, National Institute of Infectious Diseases
    • MANABE Noboru
    • Research Unit for Animal Life Sciences, Animal Resource Science Center, The University of Tokyo

Abstract

The ICR-derived glomerulonephritis (ICGN) mouse is an appropriate model for anemia associated with chronic renal disorder (CRD). Insufficient renal production of erythropoietin (EPO) induces the anemia associated with CRD. EPO mRNA is expressed in both kidneys and liver of progressing-stage ICGN mice. Hypoxic stimulation induced the EPO mRNA expression in the liver as well as in the kidneys of ICGN mice. The localization of EPO-producing cells in the liver remains controversial. Present study using an amplified <i>in situ</i> hybridization technique identified that nonparenchymal cells were the source of hepatic EPO production in ICGN mice under both normoxia and hypoxia.<br>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 68(1), 65-68, 2006

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130000448087
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • Data Source
    J-STAGE 
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