Antigenic Differences between H5N1 Human Influenza Viruses Isolated in 1997 and 2003

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  • HORIMOTO Taisuke
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation
  • FUKUDA Nao
    Laboratory of Veterinary Microbiology, Division of Veterinary Science, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University
  • IWATSUKI-HORIMOTO Kiyoko
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation
  • GUAN Yi
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital
  • LIM Wilina
    Government Virus Unit, Department of Health
  • PEIRIS Malik
    Department of Microbiology, The University of Hong Kong, Queen Mary Hospital
  • SUGII Shunji
    Laboratory of Veterinary Microbiology, Division of Veterinary Science, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University
  • ODAGIRI Takato
    Department of Virology III, National Institute of Infectious Diseases
  • TASHIRO Masato
    Department of Virology III, National Institute of Infectious Diseases
  • KAWAOKA Yoshihiro
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin

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To assess whether the antigenic properties of H5 hemagglutinin (HA) change over time due to antigenic drift, we produced a panel of monoclonal antibodies (mAbs) against the HA of the index H5N1 human influenza A virus, A/Hong Kong/156/97. By immunizing mice with a plasmid expressing this HA and boosting the initial immunization with cell lysates transfected with the plasmid, a total of six hybridomas producing HA-specific mAbs were established: four to the HA1 subunit with hemadsorption-inhibiting activity and two to the HA2 subunit. None of the mAbs to HA1 could bind to the HA of a recent human isolate, A/Hong Kong/213/2003, indicating that there are substantial antigenic differences between the H5N1 human influenza virus isolated in 1997 and that isolated in 2003.<br>

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