気管支喘息の病態におけるヒスタミンの役割と抗ヒスタミン薬の臨床的有用性の再検証  [in Japanese] Roles of Histamine in the Pathogenesis of Bronchial Asthma and Reevaluation of the Clinical Usefulness of Antihistamines  [in Japanese]

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Author(s)

    • 山内 広平 YAMAUCHI Kohei
    • 岩手医科大学医学部呼吸器・アレルギー・膠原病内科 Division of Pulmonary Medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine
    • 鹿内 俊樹 SHIKANAI Toshiki
    • 岩手医科大学医学部呼吸器・アレルギー・膠原病内科 Division of Pulmonary Medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine
    • 中村 豊 [他] NAKAMURA Yutaka
    • 岩手医科大学医学部呼吸器・アレルギー・膠原病内科 Division of Pulmonary Medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine
    • 小林 仁 KOBAYASHI Hitoshi
    • 岩手医科大学医学部呼吸器・アレルギー・膠原病内科 Division of Pulmonary Medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine
    • 小笠原 正人 OGASAWARA Masahito
    • 愛媛大学大学院医学系研究科統合生体情報学講座薬理学 Department of Pharmacology, Ehime University Graduate School of Medicine
    • 前山 一隆 MAEYAMA Kazutaka
    • 愛媛大学大学院医学系研究科統合生体情報学講座薬理学 Department of Pharmacology, Ehime University Graduate School of Medicine

Abstract

  Histamine has been reported to play an important role in pathogenesis of bronchial asthma. However, H1-blockers are not recommended as the first drug for asthma therapy in the guidelines. Histamine may play various roles in allergic airway inflammation through the H1 receptor (H1R), H2R, and H4R in immune cells including T lymphocytes and dendritic cells. We therefore evaluated its role in allergic airway inflammation with the use of histamine-deficient mice. The results suggested that histamine plays a role in the prevention of goblet cell hyperplasia. Organic cation transporter-3 (OCT-3) is thought to be a transporter of histamine. Polymorphism of OCT-3 {R120R (T/C)} was associated with the severity of asthma. Recently, it has been proposed that both asthma and allergic rhinitis should be treated as a single airway disease. Comorbidity of asthma and allergic rhinitis is very high (70-80%) and they share similar allergic inflammation. H1-blockers are recommended as first-line drugs to treat allergic rhinitis in the guidelines. Therefore H1-blockers are strongly recommended for patients with both asthma and allergic rhinitis.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 131(2), 185-191, 2011

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130000451448
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    10993156
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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