ナノマテリアルの次世代健康影響—妊娠期曝露の子に及ぼす影響  [in Japanese] Health Effects of Nanomaterials on Next Generation  [in Japanese]

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Author(s)

    • 武田 健 TAKEDA Ken
    • 東京理科大学薬学部|東京理科大学ナノ粒子健康科学研究センター Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Research Institute for Science and Technology, Tokyo University of Science|Research Center for Health Sciences of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science
    • 新海 雄介 [他] SHINKAI Yusuke
    • 東京理科大学ナノ粒子健康科学研究センター Research Center for Health Sciences of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science
    • 鈴木 健一郎 SUZUKI Ken-ichiro
    • 東京理科大学ナノ粒子健康科学研究センター Research Center for Health Sciences of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science
    • 柳田 信也 YANAGITA Shinya
    • 東京理科大学ナノ粒子健康科学研究センター Research Center for Health Sciences of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science
    • 梅澤 雅和 UMEZAWA Masakazu
    • 東京理科大学薬学部 Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Research Institute for Science and Technology, Tokyo University of Science
    • 横田 理 YOKOTA Satoshi
    • 東京理科大学薬学部 Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Research Institute for Science and Technology, Tokyo University of Science
    • 田井中 均 TAINAKA Hitoshi
    • 東京理科大学ナノ粒子健康科学研究センター Research Center for Health Sciences of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science
    • 押尾 茂 OSHIO Shigeru
    • 東京理科大学ナノ粒子健康科学研究センター|奥羽大学薬学部 Research Center for Health Sciences of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science|Department of Hygiene Chemistry, School of Pharmaceutical Sciences, Ohu University

Abstract

  In order to discuss the health effects of nanomaterials, we cannot disregard the research on the health effects of airborne particulates. It is said that many of the fine or ultrafine particles in airborne particulates originate from diesel vehicles in metropolitan areas. The results of not only animal experiments but many epidemiologic surveys and volunteer intervention experiments in humans are reported on the health effects of particles. Although the health effects of the particulate matter particle sizes below 10 μm (PM10) were investigated in the initial studies, recently even smaller particles have come to be regarded as questionable and research of the health effects of the minute particulate matter below 2.5 μm (PM2.5) has been done. However, our recent study about maternal exposure to diesel exhaust suggests that health effect study of PM0.1, particles below 0.1 μm (100 nm), namely nanoparticles, is necessary from now on. We are proceeding with the study of the health effects of various types of intentionally produced nanomaterials such as carbon black, carbon nanotube, fullerene and titanium dioxide, examining in particular their influence on next generation. Although there are differences in the sites affected and the seriousness of the damage, basically similar findings to DEPs mentioned above are being discovered in research on nanomaterials. Regardless of dosage and administration method, such as inhalation, endotracheal administration, nasal drip and subcutaneous administration, once nanomaterials enter the bloodstream of a pregnant mother mouse, they move to the offspring and have effects on them. The effects may appear as various symptoms in the process of growth after birth, and can sometimes lead to the onset and aggravation of serious diseases.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 131(2), 229-236, 2011

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130000451456
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    10993263
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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