アレルギー応答における亜鉛トランスポーターの役割  [in Japanese] Role of Zinc Transporter in Allergic Reaction  [in Japanese]

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Author(s)

    • 西田 圭吾 NISHIDA Keigo
    • 独立行政法人理化学研究所免疫・アレルギー科学総合研究センターサイトカイン制御研究グループ Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology

Abstract

  Zinc (Zn) is an essential nutrient and its deficiency causes growth retardation, immunodeficiency, and neuronal degeneration. Zn homeostasis is tightly controlled by transporting through Zn transporters and by buffering <i>via</i> metallothioneins, all of which are involved in the intricate regulation of Zn concentration and distribution in individual cells. Research in understanding of these molecules has progressed with application of genetic techniques, which allow us to clarify the diverse role of Zn <i>in vivo</i> and <i>in vitro</i>. However, the precise roles and molecular mechanism(s) of Zn's function in allergic response have not been clarified. Mast cells are granulated cells that play a pivotal role in allergic reactions. The granules of mast cells contain various chemical mediators and inflammatory cytokines that are released upon FcεRI crosslinking. In this article, I will describe a role of Zn/Zn transporter in FcεRI-mediated mast cell degranulation and cytokine production. Furthermore, Zn acts as an intracellular signaling molecule, that is, a molecule whose intracellular status is altered in response to an extracellular stimulus in mast cell, and that is capable of transducing the extracellular stimulus into an intracellular signaling event, like Ca<sup>2+</sup>. I have proposed that there are two classes of Zn signaling: “Early” and “Late” Zn signaling. In this review, I discussed how Zn and its homeostasis affect biological events especially for mast cell-mediated allergy response.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 131(1), 85-92, 2011

    The Pharmaceutical Society of Japan

Cited by:  1

Codes

  • NII Article ID (NAID)
    130000451530
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0031-6903
  • NDL Article ID
    10958082
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJPref  NDL  J-STAGE 
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