血管周囲神経リモデリングにおけるアンジオテンシン受容体の役割  [in Japanese] Role of Angiontensin Receptors on Remodeling Perivascular Nerves  [in Japanese]

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Author(s)

    • 合田 光寛 GODA Mitsuhiro
    • 岡山大学大学院医歯薬総合研究科臨床薬学 Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
    • 金 鑫 JIN Xin
    • 岡山大学大学院医歯薬総合研究科臨床薬学 Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
    • 座間味 義人 ZAMAMI Yoshito
    • 岡山大学大学院医歯薬学総合研究科医薬分子設計学 Department of Molecular Design of Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
    • 高取 真吾 TAKATORI Shingo
    • 岡山大学大学院医歯薬総合研究科臨床薬学 Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
    • 川﨑 博己 KAWASAKI Hiromu
    • 岡山大学大学院医歯薬総合研究科臨床薬学 Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Abstract

  The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fibers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar-Kyoto rats (WKY). The density of NPY-LI-containing nerve fibers was significantly greater in SHR than in WKY. SHR were treated for 7 weeks with angiotensin-converting enzyme inhibitor (0.005% temocapril), angiotensin II type-1 (AT1) receptor antagonist (0.025% losartan), or vasodilator (0.01% hydralazine) in their drinking water. Each drug treatment significantly lowered the systolic blood pressure measured using the tail-cuff method. Long-term treatment of SHR with temocapril and losartan significantly increased the density of CGRP-LI-containing nerve fibers in mesenteric arteries. Furthermore, to clarify the effect of the angiontensin II type-2 (AT2) receptor in the restoration of perivascular nerve innervation, we used the phenol-injured rat model, in which the perivascular nerves are markedly reduced by the topical application of phenol. Activation of AT2R significantly restored CGRP-LI innervation in phenol-injured rats. These results suggest that selective stimulation of AT2 receptors facilitates reinnervation of mesenteric perivascular CGRP-containing nerves.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 130(11), 1421-1425, 2010

    The Pharmaceutical Society of Japan

Cited by:  1

Codes

  • NII Article ID (NAID)
    130000451690
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0031-6903
  • NDL Article ID
    10893681
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJPref  NDL  J-STAGE 
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