抗精神病薬リスペリドンと茶葉カテキンとの相互作用メカニズム(1)エピガロカテキンガレートとの不溶性複合体の形成  [in Japanese] Mechanism of Interaction between Risperidone and Tea Catechin(1)Complex Formation of Risperidone with Epigallocatechin Gallate  [in Japanese]

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Author(s)

Abstract

  The mechanism of complexation between risperidone (RISP) and (−)-epigallocatechin gallate (EGCg) was clarified by <sup>1</sup>H-NMR and molecular modeling studies. RISP and EGCg formed an insoluble complex with a 1 : 1 stoichiometry in aqueous solution. In the <sup>1</sup>H-NMR spectra of RISP in DMSO-d<sub>6</sub>, the chemical shifts of protons neighboring the N atom on the piperizine ring clearly moved downfield upon formation of the complex. In the molecular modeling study, the <sup>1</sup>H-chemical shifts for nine optimized structures of the complex were calculated to compare them with those of the experimental results. Only one conformer with the second minimum energy for the complex supported the downfield shifts of RISP protons. It was found from the structure of the complex that the two hydrogen bonds between hydroxyl groups of the galloyl ring in EGCg and N atoms in RISP, one of which was on the piperizine ring, were formed to stabilize the complex.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 130(11), 1589-1595, 2010

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130000451712
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    10893840
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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