Stereoselective vinylogous Mukaiyama aldol reaction of α-haloenals

• Iwasaki Yoichi

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Matsui Ryosuke

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Suzuki Takahiro

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Nakazaki Atsuo

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Kobayashi Susumu

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

書誌事項

タイトル別名

• Stereoselective Vinylogous Mukaiyama Aldol Reaction of .ALPHA.-Haloenals
• Stereoselective vinylogous Mukaiyama aldol reaction of a haloenals

抄録

We have developed a high-yielding and stereoselective vinylogous Mukaiyama aldol reaction (VMAR) of α-haloenals. Contrary to the simple α,β-unsaturated aldehyde, α-haloenals were found to be reactive affording the corresponding VMAR adducts in excellent yields. Some transformations of VMAR adducts by Pd-mediated cross-coupling were also examined in order to demonstrate the synthetic utility of VMAR of α-haloenals.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 59 (4), 522-524, 2011

  公益社団法人 日本薬学会

キーワード

• vinylogous Mukaiyama aldol reaction
• α-haloenal
• stereoselectivity
• cross-coupling

詳細情報

• CRID: 1390001204172233600
• NII論文ID: 130000648979
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.59.522
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 11025195
• Web Site: http://id.ndl.go.jp/bib/11025195
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11025195
• Web Site: http://www.jstage.jst.go.jp/article/cpb/59/4/59_4_522/_pdf
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可