Myelodysplastic Syndrome with Ph Negative Monosomy 7 Chromosome following Transient Bone Marrow Dysplasia during Imatinib Treatment for Chronic Myeloid Leukemia

• Karimata Kaori

  Division of Hematology, Niigata University Medical and Dental Hospital, Japan

• Masuko Masayoshi

  Division of Stem Cell Transplantation, Niigata University Medical and Dental Hospital, Japan

• Ushiki Takashi

  Division of Hematology, Niigata University Medical and Dental Hospital, Japan

• Kozakai Takashi

  Division of Hematology, Niigata University Medical and Dental Hospital, Japan

• Shibasaki Yasuhiko

  Division of Hematology, Niigata University Medical and Dental Hospital, Japan

• Yano Toshio

  Division of Hematology, Niigata University Medical and Dental Hospital, Japan

• Abe Takashi

  Division of Hematology, Niigata University Medical and Dental Hospital, Japan

• Moriyama Masato

  Division of Hematology, Niigata University Medical and Dental Hospital, Japan

• Toba Ken

  Division of Hematology, Niigata University Medical and Dental Hospital, Japan

• Furukawa Tatsuo

  Division of Stem Cell Transplantation, Niigata University Medical and Dental Hospital, Japan

• Aizawa Yoshifusa

  Division of Hematology, Niigata University Medical and Dental Hospital, Japan

Abstract

We describe a 60-year-old Japanese patient with chronic myeloid leukemia (CML) who developed myelodysplastic syndrome (MDS) with Ph negative monosomy 7 chromosome following transient bone marrow dysplasia during imatinib treatment. Most cases that developed chromosomal abnormality in Ph negative cells during imatinib therapy were reported to have less clinical implications, while rare cases developed MDS/AML. The present case suggested that metaphase karyotype analysis and bone marrow examination should be performed for the long term follow-up under imatinib treatment in cases showing cytopenia. The results also suggested that monosomy 7 in Ph negative cells may be an indicator of a poor prognosis.<br>

Journal

• Internal Medicine

  Internal Medicine 50 (5), 481-485, 2011

  The Japanese Society of Internal Medicine

Keywords

• CML
• MDS
• monosomy 7
• Ph negative cells

Details

• CRID: 1390282679849281536
• NII Article ID: 130000649865
• DOI: 10.2169/internalmedicine.50.4481
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/50/5/50_5_481/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012013294
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed