Gastroptosis is Associated with Less Dyspepsia, Rather than a Cause of Dyspepsia, in Japanese Persons

• Kusano Motoyasu

  Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Japan

• Moki Fumitaka

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Hosaka Hiroko

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Shimoyama Yasuyuki

  Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Japan

• Kawamura Osamu

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Nagoshi Atsuto

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Maeda Masaki

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Kuribayashi Shikou

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Zai Hiroaki

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Mizuide Masafumi

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Horikoshi Tsutomu

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Mori Masatomo

  Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan

• Akuzawa Masako

  The Hidaka Hospital, Japan

Abstract

Objective Gastroptosis is recognized by its characteristic appearance on barium studies. The present prospective study assessed the relationship between gastroptosis and dyspeptic symptoms.<br> Methods Japanese subjects underwent health screening, and gastroptosis was diagnosed by barium studies. Consecutive subjects (500 women and 167 men) with gastroptosis were identified and the same number of age-matched subjects without gastroptosis were selected as controls. Dyspepsia was classified as reflux-like (heartburn and belching), dysmotility-like (bloating and fullness), or ulcer-like dyspepsia (epigastralgia) based on the Rome II criteria.<br> Results Body mass index was significantly lower in women with gastroptosis than in controls [19.7±1.83 (SD) vs. 23.4±3.70, p<0.0001], and also in men (19.7±2.00 vs. 23.9±2.89, p<0.0001). The incidence of dyspepsia was significantly lower in women with gastroptosis than in controls (56/500 vs. 87/500, p<0.01) and also in men (10/167 vs. 25/167, p<0.05), especially in women with ulcer-like dyspepsia (15/500 vs. 32/500, p<0.05) and in men with reflux-like dyspepsia (2/167 vs. 12/167, p<0.05). By logistic regression analysis, gastroptosis was associated with a lower risk of dyspepsia (odds ratio: 0.62, 95% CI: 0.405-0.941, p=0.025) and ulcer-like dyspepsia (odds ratio: 0.36, 95% CI: 0.177-0.726, p=0.004) in women.<br> Conclusion Dyspeptic symptoms were significantly less common in subjects with gastroptosis. Accordingly, gastroptosis may protect against dyspeptic symptoms, rather than causing functional dyspepsia.<br>

Journal

• Internal Medicine

  Internal Medicine 50 (7), 667-671, 2011

  The Japanese Society of Internal Medicine

Keywords

• body mass index
• dysmotility-like dyspepsia
• gastroptosis
• reflux-like dyspepsia
• ulcer-like dyspepsia

Details

• CRID: 1390001204871035264
• NII Article ID: 130000650037
• DOI: 10.2169/internalmedicine.50.4582
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/50/7/50_7_667/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012093310
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed