Clinical Study Concerning the Relationship between Community-Acquired Pneumonia and Viral Infection in Northern Thailand

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  • Hara Koyu
    Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
  • Yahara Koji
    Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan Division of Biostatistics, Kurume University School of Medicine, Japan Life Science Systems Department, Fujitsu Kyushu Systems Ltd., Japan
  • Gotoh Kenji
    Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
  • Nakazono Yoko
    Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
  • Kashiwagi Takahito
    Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
  • Imamura Yoshihiro
    Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
  • Hamada Nobuyuki
    Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan
  • Khositsakulchai Weerayut
    Nakornping Hospital, Thailand
  • Sanchai Tippaya
    Nakornping Hospital, Thailand
  • Khantawa Banyong
    Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University, Thailand
  • Tharavichitkul Prasit
    Department of Microbiology, Faculty of Medicine, Chiang Mai University, Thailand
  • Maneekarn Niwat
    Department of Microbiology, Faculty of Medicine, Chiang Mai University, Thailand
  • Sirisanthana Thira
    Research Institute for Health Sciences, Chiang Mai University, Thailand
  • Watanabe Hiroshi
    Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medicine, Japan

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Abstract

Objective The etiological agents associated with community-acquired pneumonia (CAP) in Thailand have been studied extensively in bacterial pathogens, but not in viral pathogens. To clarify the association of viral pathogens with CAP, we conducted a comprehensive study of viral and bacterial pathogens in patients with CAP.<br> Methods We enrolled 119 hospitalized patients with CAP in Nakornping Hospital, Chiang Mai, Thailand between 2006 and 2008. The severity of pneumonia was classified and the risk factors for death were estimated. Bacterial and fungal pathogens were determined from specimens taken from blood and sputum, and viral pathogens were identified from nasopharyngeal specimens by RT-PCR using primers specific for 7 respiratory viruses.<br> Results Overall, 29 patients were HIV-infected and 90 patients were non-HIV-infected. The microbial pathogens most commonly isolated among HIV-infected patients were: 4 Klebsiella pneumoniae, 4 Mycobacterium tuberculosis and 3 Haemophilus influenzae. Among non-HIV infected patients, predominant microbial pathogens were: 6 Pseudomonas aeruginosa, 5 Haemophilus influenzae and 4 Klebsiella pneumoniae. As for viral pathogens for CAP, influenza virus was identified from 2 HIV-infected patients and 5 non-HIV infected patients. In addition, human rhinovirus (HRV) and respiratory syncytial virus (RSV) were identified from 2 patients each among non-HIV-infected patients.<br> Conclusion Our study demonstrates that the most common viral agent was influenza virus (5%), followed by HRV (2%) and RSV (2%) among CAP patients in northern Thailand. The underlying chronic obstructive pulmonary disease (COPD) seems to be correlated with the severity of illness.<br>

Journal

  • Internal Medicine

    Internal Medicine 50 (9), 991-998, 2011

    The Japanese Society of Internal Medicine

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