Specific Interaction between Ca2+ and Anionic Lipids in Cancer Cells along with Apoptosis

• Goto Koichi

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

• Tatsumi Kazuki

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

• Nagata Toshihiro

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

• Komizu Yuji

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

• Ueoka Ryuichi

  Division of Applied Life Science, Graduate School of Engineering, Sojo University

抄録

Markedly inhibitory effects of Ca²⁺ on the growth of human tumor cells were attained through the induction of apoptosis in vitro. On the other hand, a good correlation between the growth inhibition effects of Ca²⁺ and the amounts of phosphatidylserines (PS) in the cell membranes (plasma membranes) was obtained. Furthermore, the decrease of membrane fluidity and the localization of lipid microdomains “lipid rafts” in the cell membranes were observed in the presence of Ca²⁺. The findings in this study suggest that Ca²⁺ could induce apoptosis toward tumor cells through the localization of lipid rafts in plasma membranes by the specific interactions between extracellular Ca²⁺ and PS.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 34 (3), 439-442, 2011

  公益社団法人 日本薬学会

キーワード

• calcium
• tumor cell
• apoptosis
• phosphatidylserine
• lipid raft

詳細情報

• CRID: 1390282679604201984
• NII論文ID: 130000657828
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.34.439
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 10990209
• Web Site: http://id.ndl.go.jp/bib/10990209
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10990209
• Web Site: http://www.jstage.jst.go.jp/article/bpb/34/3/34_3_439/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012000208
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
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• 抄録ライセンスフラグ: 使用不可