Regulation of Dopaminergic Neuronal Activity by Heart-type Fatty Acid Binding Protein in the Brain

• YAMAMOTO Yui

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University

• SHIODA Norifumi

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University

• OWADA Yuji

  Department of Organ Anatomy, Graduate School of Medicine, Yamaguchi University

• FUKUNAGA Kohji

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University

Bibliographic Information

Other Title

• 心臓型脂肪酸結合タンパク質による中枢ドパミン神経活動の調節
• シンゾウガタ シボウサン ケツゴウ タンパクシツ ニ ヨル チュウスウ ドパミン シンケイ カツドウ ノ チョウセツ

Abstract

  Haloperidol as a potent dopamine D2 receptor (D2R) antagonist was a major tranquilizer to treat schizophrenia patients. However, the D2R blocking action in dorsal striatum is thought to cause extrapyramidal symptoms as adverse effects. However, the pathophysiological mechanism underlying extrapramidal symptoms induced by chronic treatment of haloperidol remains unclear. We recently found that lacking of heart-type fatty acid binding protein (H-FABP) in the brain aggravate catalepsy behavior induced by haloperidol. Here, we examined neuronal mechanism of augmentation of haloperidol-induced catalepsy in H-FABP null mice. Notably, catalepsy induced by haloperidol, a D2 antagonist, is augmented, whereas catalepsy induced by SCH23390, a D1 antagonist, was not affected in H-FABP null mice. Interestingly, haloperidol-induced acetylcholine (ACh) release in the dorsal striatum was markedly enhanced in H-FABP null mice compared to wild mice. We also defined the co-localization of D2R with H-FABP in the ACh interneurons in the striatum. Taken together, H-FABP regulates dopaminergic neuronal activity through interaction with D2R in rodent brain. The increased ACh release in the striatum accounts for haloperidol-induced catalepsy.<br>

Journal

• YAKUGAKU ZASSHI

  YAKUGAKU ZASSHI 131 (4), 497-501, 2011-04-01

  The Pharmaceutical Society of Japan

Keywords

• extrapyramidal symptom
• catalepsy
• haloperidol
• dopamine D2 receptor
• heart-type fatty acid binding protein

Details

• CRID: 1390282681104124160
• NII Article ID: 130000678828
• NII Book ID: AN00284903
• DOI: 10.1248/yakushi.131.497
• ISSN: 13475231
• ISSN: 00316903
• NDL BIB ID: 11111783
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11111783
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/131/4/131_4_497/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012000599
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed