Function of K+-Cl- Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells
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- Fujii Takuto
- Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Fujita Kyosuke
- Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Takeguchi Noriaki
- Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Sakai Hideki
- Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Bibliographic Information
- Other Title
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- Function of K⁺-Cl⁻ cotransporters in the acid secretory mechanism of gastric parietal cells
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Abstract
Gastric proton pump (H+, K+-ATPase) secretes H+ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl−- and K+-transporting proteins are required. Recent our studies have demonstrated that K+–Cl− cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na+, K+-ATPase in the basolateral membrane, and KCC4 is associated with H+, K+-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 34 (6), 810-812, 2011
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679604059904
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- NII Article ID
- 130000738053
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 11095136
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed