活性ペプチドのＤＤＳ　腸管の免疫能とＢＲＭ経口投与

DOI 被引用文献2件

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タイトル別名
  • Drug delivery system. Effect of orally administered biological response modifiers(BRMs) on immunity of the gut.
  • Effect of orally administered biological response modifers (BRMs) on immunity of the gut
  • 腸管の免疫能とBRM経口投与

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During last two decades cancer immunotherapy has become popular, and various biological response modifiers (BRMs) have been applied. We have studied an oral application of BRMs, especially PSK and OK-432 for immunotherapy of gastrointestinal cancer. Orally administered PSK and OK-432 augment antitumor immunity, such as NK cell activity, responsiveness to lectins, etc. of spleen and mesenteric lymph node lymphocytes of the mice transplanted with cecal tumor. They also augment antitumor immunity of peripheral blood and regional node lymphocytes in patients with gastric or colorectal cancer. The patients were orally administered with OK-432 after resection of gastric cancer, and their survival rate was significantly higher than that of the patients administered intradermally with OK-432 and of the patients administered orally with placebo. There results suggest that oral application of BRM may be beneficial for immunotherapy of gastrointestinal cancer.

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