〔エチルＰ‐（６‐グアニジノヘキサノイルオキシ）ベンゾエート〕メタンスルホネート（ＦＯＹ）のキニン生成系および線溶活性系に対する作用

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  • Effects of (Ethyl <I>p</I>-(6-guanidinohexanoyloxy)benzoate) methanesulfonate (FOY) on kinin formation and fibrinolytic activity.
  • Ethyl p 6 guanidinohexanoyloxy benzoate

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Inhibitory effects of (Ethyl p-(6-guanidinohexanoyloxy)benzoate)methanesulf on ate (FOY) on kinin formation (in vitro and in vivo) and the fibrinolytic activity (in vivo) were examined and compared with other inhibitors. Inhibitory effect on kinin forming activity (in vitro) of various enzymes was measured in the guinea pig ileum. FOY and Trasylol inhibited the kinin forming activities of trypsin, pancreas kaliikrein and plasma kallikrein. Soybean trypsin inhibitor inhibited kinin forming activities of trypsin and plasma kallikrein, but not of pancreas kallikrein. Bradykininlike substance was formed in the perfusate when the rat's paw was heated at 46°C FOY and Trasylol added to the perfusion fluid produced a potent inhibition of the formation of bradykininlike substance. When administered i.v., FOY and Trasylol did not inhibit the formation of bradykinin-like substance. In the dog, activation of plasmin in the circulatory blood and increase of hemorrhagic tendency were caused by the i.v. administration of human serum plus streptokinase. Such responses were inhibited with a previous i.v. infusion of FOY and t-AMCHA. From the above findings, it may be concluded that FOY has inhibitory effects on kinin formation and fibrinolytic activity.

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