Ｍｅｑｕｉｔａｚｉｎｅの抗アレルギー作用　（第２報）　　Ｉｎ　ｖｉｖｏの成績

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タイトル別名
  • Antiallergic effects of mequitazine. 2. In vivo experiments.
  • Mequitazine ノ コウ アレルギー サヨウ 2 In vivo ノ

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抄録

Antiallergic effects of mequitazine were investigated in vivo and compared with those of ketotifen and disodium cromoglycate (DSCG). The results obtained were as follows: 1) Mequitazine in doses of 2 and 5 mg/kg given, p.o., 1 hr prior to antigen challenge inhibited dose-dependently the 48-hr passive cutaneous anaphylaxis in rats. Five mg/kg of mequitazine showed almost the same extent of inhibitory activity as that of 1 mg/kg of ketotifen. An i.v. administration of 1 mg/kg DSCG 1 min before antigen challenge also showed a marked inhibition. 2) The experimental asthma induced by challenge with an i.v. injection of antigen in passively sensitized guinea pigs was fairly inhibited by the pretreatment with 5 mg/kg of mequitazine administered p.o., although 2 mg/kg of this drug showed only a slight inhibition. 3) The experimental asthma induced by aerosolized antigen was also fairly inhibited by the pretreatment with 5 mg/kg of mequitazine given p.o.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 92 (2), 159-165, 1988

    公益社団法人 日本薬理学会

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