Free Radical in Brain of Spontaneously Epileptic Rat(SER).

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  • MORI Akitane
    <I>Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School</I>
  • KATAYAMA Yasuto
    <I>Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School</I>
  • EDAMATSU Rei
    <I>Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School</I>
  • ITOH Takehiko
    <I>Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School</I>
  • YUFU Katsumi
    <I>Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School</I>
  • NODA Yasuko
    <I>Department of Biochemistry, Tottori University</I>
  • TAKAYAMA Misako
    <I>Faculty of Medicine and College of Medical Care Technology, Tottori University</I>

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Other Title
  • ＳＥＲの脳内フリーラジカル

Abstract

The spontaneously epileptic rat (SER; zi/zi, tm/tm) is the double mutant obtained by mating the tremor rat (TRM; tm/tm) with the zitter rat (ZI; zi/zi), exhibits tonic convulsions and absencelike seizures without external stimulation, and has marked vacuolation and hypomyelination in the brain. Vacuole formation is seen widely in the brain of TRM rat as same as SER. As free radical and its related materials may possibly participate to form vacuole in the brain of SER and TRM rats, free radicals (⋅C, ⋅OH, ⋅H), TBARS level, SOD activity and content of fatty acids were investigated.<BR>During maturation, free radicals and Cu, Zn-SOD activities in the brain of SER did not change, but TBARS levels in cerebellum and pons-medulla oblongata increased. On the other hand, in pons-medulla oblongata of TRM rats, Cu, Zn-SOD activity and ⋅OH radical increased during maturation. In the same region of the 24-week-old TRM rats, TBARS level increased and the content of arachidonic acid (C22: 4) decreased significantly compared with those in WTC rats. These results suggest that vacuole formation may be caused by lipid peroxidation of membrane.

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