書誌事項
- タイトル別名
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- Effect of elcatonin on experimental osteoporosis induced by ovariectomy and low calcium diet in beagles
- ランソウ テキシュツ ト テイ Ca ショク ニ ヨル イヌ ノ ジッケンテキ
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抄録
Effect of elcatonin, a synthesized analogue of eel calcitonin, on experimental osteoporosis in beagles induced by ovariectomy and a low calcium diet was studied. Twelve female beagles, 15-18 months old, were divided equally into 3 groups. The first group of beagles were ovariectomized and then fed a low calcium diet, Ca: 0.08%, (ovariectomy plus low Ca diet group) ; the second group was subjected to the same procedure and diet plus daily injection of elcatonin, 1.0 u/kg, i.m., (elcatonin group); and the third group was fed a standard diet, Ca: 1.36%, (control group) for 6 months. The undecalcified bone sections from the iliac crest were analyzed using histomorphometric methods following in vivo double labeling with Calcein®. In the ovariectomy plus low Ca diet group, there were a decrease in trabecular bone volume and an increase in both resorption and formation surface of the trabeculae compared with the control group. These changes of trabecular bone volume and resorption surface were significantly prevented by daily injection of elcatonin. The increase of formation surface of trabeculae and mineral appositional rate was noted in the elcatonin group in comparison with the ovariectomy plus low Ca diet group. These results suggested that elcatonin could prevent bone loss caused by deficiency of sex hormone and dietary calcium.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 84 (1), 91-98, 1984
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679247145984
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- NII論文ID
- 10008400431
- 130000761053
- 10017133266
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- NII書誌ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3000709
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- PubMed
- 6489866
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可