Systolic Time Intervals in Patients with Progressive Muscular Dystrophy of the Duchenne Type
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- MATSUDA Mitsuo
- First Department of Internal Medicine, Faculty of Medicine, University of Tokyo Department of Neurology, Faculty of Medicine, University of Tokyo Department of Pathology, Faculty of Medicine, University of Tokyo
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- AKATSUKA Nobuharu
- First Department of Internal Medicine, Faculty of Medicine, University of Tokyo Department of Neurology, Faculty of Medicine, University of Tokyo Department of Pathology, Faculty of Medicine, University of Tokyo
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- YAMAGUCHI Tetsu
- First Department of Internal Medicine, Faculty of Medicine, University of Tokyo Department of Neurology, Faculty of Medicine, University of Tokyo Department of Pathology, Faculty of Medicine, University of Tokyo
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- SAITO Tadanori
- First Department of Internal Medicine, Faculty of Medicine, University of Tokyo Department of Neurology, Faculty of Medicine, University of Tokyo Department of Pathology, Faculty of Medicine, University of Tokyo
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- TAKAHASHI Hisako
- First Department of Internal Medicine, Faculty of Medicine, University of Tokyo Department of Neurology, Faculty of Medicine, University of Tokyo Department of Pathology, Faculty of Medicine, University of Tokyo
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- TOMOMATSU Kenichi
- First Department of Internal Medicine, Faculty of Medicine, University of Tokyo Department of Neurology, Faculty of Medicine, University of Tokyo Department of Pathology, Faculty of Medicine, University of Tokyo
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- TAMURA Tsutomu
- First Department of Internal Medicine, Faculty of Medicine, University of Tokyo Department of Neurology, Faculty of Medicine, University of Tokyo Department of Pathology, Faculty of Medicine, University of Tokyo
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- FURUKAWA Tetsuo
- First Department of Internal Medicine, Faculty of Medicine, University of Tokyo Department of Neurology, Faculty of Medicine, University of Tokyo Department of Pathology, Faculty of Medicine, University of Tokyo
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- MURAKAMI Toshikazu
- First Department of Internal Medicine, Faculty of Medicine, University of Tokyo Department of Neurology, Faculty of Medicine, University of Tokyo Department of Pathology, Faculty of Medicine, University of Tokyo
書誌事項
- タイトル別名
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- Systolic Time Intervals in Patients wit
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抄録
Systolic time intervals (STIs) were measured in 57 patients with progressive muscular dystrophy (PMD) of the Duchenne type, and were correlated with the stages of physical disability. The total electromechanical systole (Q-A2), pre-ejection period (PEP), and left ventricular ejection time (LVET) were corrected for heart rate using the linear regression equations calculated from 91 normal subjects. Each systolic time interval index (STII), i.e. corrected STI, was analyzed.<br>In 15 ambulatory patients (Group P-1), the STIls did not differ significantly from those in normal controls. In 37 patients who were unable to walk (Group P-2) and 5 patients who were confined to bed (Group P-3), there was a significant increase (p<0.001) in the PEP index (PEPI), a decrease (p<0.001) in the LVET index (LVETI), and an increase (p<0.001) in the PEP/LVET compared with those in controls. The PEPI (p<.001), LVETI (p<0.025), and PEP/LVET (p<0.001) in Group P-2 differed significantly from those in Group P-1. In Group P-3, the PEPI (p<0.005), LVET (p<0.001), and PEP/LVET (p<0.001) were significantly changed in comparison with those in Group P-2.<br>Remarkable myocardial histopathologic changes suggestive of dystrophy were revealed in autopsies of 3 patients who had been in the severely disabled stage and had shown impaired STIs.<br>It is suggested that cardiac function in patients with moderate to ad-vanced PMD of the Duchenne type is deteriorated in proportion to the disability stages, i.e. the severity of changes in the skeletal muscles.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 18 (5), 638-651, 1977
International Heart Journal刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001205038216448
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- NII論文ID
- 130000762872
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- NII書誌ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL書誌ID
- 1912915
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- PubMed
- 926310
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可