Specific Elevation of Thromboxane Synthetase Activity and Leukotriene C Formation in Malignant Hypertension in the Hypothalamus of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)
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The main metabolic alterations in the hypothalamus of SHRSP that the endogenous vaso-dilating prostaglandin I<sub>2</sub> biosynthesis was not so enough adaptively enhanced as in SHRSR and that not only the vaso-constricting thromboxane A<sub>2</sub> biosynthesis but also the edema-causative leukotriene C formation elevated much higher than in SHRSR would reasonably contribute to a cause of malignant hypertension prior to stroke.
- Japanese Heart Journal
Japanese Heart Journal 24(5), 779-781, 1983
International Heart Journal Association