Specific Elevation of Thromboxane Synthetase Activity and Leukotriene C Formation in Malignant Hypertension in the Hypothalamus of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)

The main metabolic alterations in the hypothalamus of SHRSP that the endogenous vaso-dilating prostaglandin I₂ biosynthesis was not so enough adaptively enhanced as in SHRSR and that not only the vaso-constricting thromboxane A₂ biosynthesis but also the edema-causative leukotriene C formation elevated much higher than in SHRSR would reasonably contribute to a cause of malignant hypertension prior to stroke.