Specific Elevation of Thromboxane Synthetase Activity and Leukotriene C Formation in Malignant Hypertension in the Hypothalamus of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)

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Author(s)

    • Ohtsu Eiji
    • Department of Pediatrics, Kitasato University School of Medicine
    • Abe Kumiko
    • Department of Pediatrics, Kitasato University School of Medicine
    • Itoh Hisao
    • The Research Institute for Cancer and Tuberculosis, Tohoku University
    • Matsuzawa Taiju
    • The Research Institute for Cancer and Tuberculosis, Tohoku University
    • Yashiro Kimio
    • Department of Pediatrics, Kitasato University School of Medicine

Abstract

The main metabolic alterations in the hypothalamus of SHRSP that the endogenous vaso-dilating prostaglandin I<sub>2</sub> biosynthesis was not so enough adaptively enhanced as in SHRSR and that not only the vaso-constricting thromboxane A<sub>2</sub> biosynthesis but also the edema-causative leukotriene C formation elevated much higher than in SHRSR would reasonably contribute to a cause of malignant hypertension prior to stroke.

Journal

  • Japanese Heart Journal

    Japanese Heart Journal 24(5), 779-781, 1983

    International Heart Journal Association

Codes

  • NII Article ID (NAID)
    130000764176
  • Text Lang
    ENG
  • ISSN
    0021-4868
  • Data Source
    J-STAGE 
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