Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders.

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  • OBANA Nobuya
    The Department of Gastroenterology, Tohoku University Postgraduate School of Medicine
  • TAKAGI Sho
    The Department of Gastroenterology, Tohoku University Postgraduate School of Medicine
  • KINOUCHI Yoshitaka
    The Department of Gastroenterology, Tohoku University Postgraduate School of Medicine
  • TOKITA Yoshihisa
    The Department of Molecular Metabolism and Diabetes, Tohoku University Postgraduate School of Medic
  • SEKIKAWA Akihiro
    The Department of Molecular Metabolism and Diabetes, Tohoku University Postgraduate School of Medic
  • TAKAHASHI Seiichi
    The Department of Gastroenterology, Tohoku University Postgraduate School of Medicine
  • HIWATASHI Nobuo
    The Department of Gastroenterology, Tohoku University Postgraduate School of Medicine
  • OIKAWA Shinichi
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Nippon Medical School
  • SHIMOSEGAWA Tooru
    The Department of Gastroenterology, Tohoku University Postgraduate School of Medicine

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Objective Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis.<br> Patients and Methods We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases.<br> Results The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p=0.0014).<br> Conclusion Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.<br>(Internal Medicine 42: 150-153, 2003)

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  • Internal Medicine

    Internal Medicine 42 (2), 150-153, 2003

    一般社団法人 日本内科学会

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