Syndrome of Inappropriate Secretion of Antidiuretic Hormone Associated with Multiple Sclerosis.
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- SAKAI Naoki
- the First Department of Medicine, Hamamatsu University School of Medicine
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- MIYAJIMA Hiroaki
- the First Department of Medicine, Hamamatsu University School of Medicine
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- SHIMIZU Takako
- the First Department of Medicine, Hamamatsu University School of Medicine
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- ARAI Kazumori
- the Second Department of Pathology, Hamamatsu University School of Medicine
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抄録
A 63-year-old man who developed episodes of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) twice in the course of multiple sclerosis (MS) is reported. SIADH in this patient occurred only during the administration of antibiotics (sulbactam/cefoperazone, SBT/CPZ). At autopsy, demyelinating lesions in the optic nerves, cervical and thoracic spinal cord, and areas adjacent to the lateral ventricles were observed. Destruction and loss of neuronal cells were found in the supraoptic nuclei. Lymphocytic infiltration was observed in the area adjacent to the supraoptic nuclei. Destruction and swelling of axons and reactive astrocytic gliosis were observed in the hypothalamus. SIADH associated with MS is rare and the histological findings in such a case have not yet been reported. It is suggested that the development of SIADH in MS may be related to the damage in the supraoptic nuclei of the hypothalamus.<br>(Internal Medicine 31:463-466, 1992)
収録刊行物
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- Internal Medicine
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Internal Medicine 31 (4), 463-466, 1992
一般社団法人 日本内科学会