Cell Profile and Elastase Activity in Diffuse Panbronchiolitis Investigated by Bronchoalveolar and Bronchial Lavage.
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- YASUOKA Susumu
- the Third Department of Internal Medicine, School of Medicine, Tokushima University
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- FUJISAWA Kenji
- the Third Department of Internal Medicine, School of Medicine, Tokushima University
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- UETA Yujr
- the Third Department of Internal Medicine, School of Medicine, Tokushima University
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- NII Yasuo
- the Third Department of Internal Medicine, School of Medicine, Tokushima University
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- INOUE Ikuko
- the Third Department of Internal Medicine, School of Medicine, Tokushima University
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- TANI Kenji
- the Third Department of Internal Medicine, School of Medicine, Tokushima University
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- OHGUSHI Fumitaka
- the Third Department of Internal Medicine, School of Medicine, Tokushima University
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- OGURA Takeshi
- the Third Department of Internal Medicine, School of Medicine, Tokushima University
抄録
To examine the mechanism of tissue damage which causes bronchiolectasis in diffuse pan-bronchiolitis (DPB), the cellular components, elastase and its main inhibitor, alpha 1-protease inhibitor (α1-PI) were measured in bronchoalveolar and bronchial lavage fluid (BALF and BLF) from 14 DPB patients. A predominant increase in the neutrophil count was observed in DPB. Elastase activity in BALF and BLF was about 1, 000-fold higher in the DPB group than in the control group. An inhibitor study and a positive correlation between elastase activity and the neutrophil count in both lavage fluids from the DPB group indicated that the activity was mainly that of neutrophil elastase. Western blot analysis of αl-PI showed that most of the α1-PI in the lavage fluids from DPB group was degraded. These results indicated that neutrophil infiltration increases the level of elastase in the DPB lesions ; this increase seems to be closely related to tissue damage.<br>(Internal Medicine 31 : 599-605, 1992)
収録刊行物
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- Internal Medicine
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Internal Medicine 31 (5), 599-605, 1992
一般社団法人 日本内科学会
