Rapid Progression of Hepatocellular Carcinoma in a Patient with Autoimmune Hepatitis
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- Yamamoto Kayo
- The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
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- Hiura Masaaki
- The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
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- Tabaru Akinari
- The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
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- Honma Yuichi
- The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
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- Narita Ryoichi
- The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
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- Abe Shintaro
- The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
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- Shimajiri Shohei
- Department of Pathology and Cell Biology, University of Occupational and Environmental Health, Japan
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- Okamoto Kohji
- The First Department of Surgery, University of Occupational and Environmental Health, Japan
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- Yamaguchi Koji
- The First Department of Surgery, University of Occupational and Environmental Health, Japan
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- Harada Masaru
- The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
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抄録
We describe a case of a 69-year-old woman who developed rapidly progressive hepatocellular carcinoma (HCC) associated with autoimmune hepatitis (AIH) after a 7-year follow-up. Markers for viral hepatitis were negative. Serum tumor markers including alpha-fetoprotein and prothrombin induced by vitamin K absence II rose suddenly, and a large tumor was detected in spite of regular surveillance for HCC. Surgical treatment was performed. The resected liver specimen revealed well to moderately differentiated HCC. Ki67 staining showed rapid proliferation of the HCC. Although the incidence of HCC in patients with AIH has been unclarified, the possible complication by HCC must not be overlooked.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 50 (13), 1409-1413, 2011
一般社団法人 日本内科学会