Enhanced Inflammation in Epicardial Fat in Patients With Coronary Artery Disease

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著者

    • Hirata Yoichiro
    • Department of Cardiovascular Medicine, Institute of Health Bioscience, The University of Tokushima Graduate School
    • Kitagawa Tetsuya
    • Department of Cardiovascular Surgery, Institute of Health Bioscience, The University of Tokushima Graduate School
    • Sata Masataka
    • Department of Cardiovascular Medicine, Institute of Health Bioscience, The University of Tokushima Graduate School
    • Kurobe Hirotsugu
    • Department of Cardiovascular Surgery, Institute of Health Bioscience, The University of Tokushima Graduate School
    • Akaike Masashi
    • Department of Cardiovascular Medicine, Institute of Health Bioscience, The University of Tokushima Graduate School
    • Chikugo Fumio
    • Department of Cardiovascular Surgery, Tokushima Prefectural Central Hospital
    • Hori Takaki
    • Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital
    • Bando Yoshimi
    • Department of Pathology, The University of Tokushima Hospital
    • Nishio Chika
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Higashida Mayuko
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Nakaya Yutaka
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School

抄録

It has been hypothesized that epicardial fat, a local visceral fat depot with close proximity to coronary arteries, may serve as a source of inflammatory cytokines and cells in coronary atherosclerotic lesions. Here, we characterized infiltration of inflammatory cells and expression of adipocytokines in epicardial adipose tissue in patients with and without coronary artery disease (CAD). Pare samples were obtained from epicardial and subcutaneous adipose tissue during elective cardiac surgery (CAD, <i>n</i> = 8; non-CAD, <i>n</i> = 9). Inflammatory cell infiltration was investigated by immunohistochemical staining using antibodies against CD3, CD4, CD8 and CD68. Expression of adipocytokines was evaluated by real-time quantitative reverse transcription-polymerase chain reaction. Infiltration of macrophages and CD8-positive T cells in the epicardial adipose tissue in the CAD group was greater than that in the non-CAD group. In contrast, there was no significant difference between the two groups in the number of inflammatory cells in subcutaneous adipose tissue. No statistical difference could be found between the CAD group and the non-CAD group in the expression levels of adiponectin and inflammatory cytokines in epicardial adipose tissue. Our findings suggest that inflammatory cell infiltration is enhanced in epicardial adipose tissue, but not in subcutaneous fat, in patients with coronary artery disease. Chronic inflammation in epicardial fat may influence the pathogenesis of coronary atherosclerosis.

収録刊行物

  • International Heart Journal

    International Heart Journal 52(3), 139-142, 2011

    一般社団法人 インターナショナル・ハート・ジャーナル刊行会

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    130000770910
  • 本文言語コード
    ENG
  • 資料種別
    雑誌論文
  • ISSN
    1349-2365
  • データ提供元
    CJP引用  J-STAGE 
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