Serum C-Reactive Protein Levels and Death and Cardiovascular Events in Mild to Moderate Chronic Kidney Disease
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- Koeda Yorihiko
- Department of Internal Medicine, Iwate Medical University
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- Nakamura Motoyuki
- Department of Internal Medicine, Iwate Medical University
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- Tanaka Fumitaka
- Department of Internal Medicine, Iwate Medical University
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- Onoda Toshiyuki
- Department of Preventive Medicine, Iwate Medical University
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- Itai Kazuyoshi
- Department of Preventive Medicine, Iwate Medical University
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- Tanno Kozo
- Department of Preventive Medicine, Iwate Medical University
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- Ohsawa Masaki
- Department of Preventive Medicine, Iwate Medical University
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- Makita Shinji
- Department of Internal Medicine, Iwate Medical University
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- Ishibashi Yasuhiro
- Department of Internal Medicine, Iwate Medical University
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- Koyama Tomiko
- Iwate Health Service Association
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- Yoshida Yuki
- Department of Neurosurgery, Iwate Medical University
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- Omama Shin-ichi
- Department of Neurosurgery, Iwate Medical University
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- Ogasawara Kuniaki
- Department of Neurosurgery, Iwate Medical University
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- Ogawa Akira
- Department of Neurosurgery, Iwate Medical University
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- Kuribayashi Toru
- Department of Health and Physical Education, Faculty of Education, Iwate University
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- Okayama Akira
- The First Institute of Health Service, Japan Anti-tuberculosis Association
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抄録
Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular (CV) disease. Elevated circulating levels of high sensitivity C-reactive protein (hsCRP) have been suggested to be associated with high risk of CV disease. It is uncertain whether the CV risk in CKD can be stratified by hsCRP levels in the Japanese population. Baseline data including serum hsCRP and creatinine levels were determined in the general population. Estimated glomerular filtration rate (eGFR) was calculated using a modified MDRD equation, and CKD was defined as eGFR below 60 mL/minute/1.73m2. We analyzed 1,074 male subjects with mild to moderate CKD (mean age, 70.4 years). CV events (stroke and myocardial infarction) and all-cause death were surveyed prospectively. The CKD subjects were followed for 5.1 years, and 72 CV events and 115 all-cause deaths were found (composite endpoint). After adjustment for established CV risk factors, hazard ratios (HRs) for the endpoint were significantly increased according to the hsCRP quintile (P < 0.001), and HR for the highest (versus the lowest) quintile was 2.77 (95% CI; 1.61-4.77). These results suggest that serum hsCRP measurement is a useful tool for the risk stratification of CV events and death in CKD male subjects selected from the general population.
収録刊行物
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- International Heart Journal
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International Heart Journal 52 (3), 180-184, 2011
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282680201349888
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- NII論文ID
- 130000770918
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- ISSN
- 13493299
- 13492365
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可