大腸癌化学療法の現況

• 小川 一誠

  愛知県がんセンター

書誌事項

タイトル別名

• Current Status of Chemotherapy on Colorectal cancer

抄録

This presentation reviews current status of chemotherapy for advanced disease and adjuvant chemotherapy.<BR>Advanced Disease : protracted continuous intravenous infusion of low doses (200-300mg/m²/d) of 5-fluorouracil (5FU) has obtained response rates >30% and biochemical modulation using a combination consisting of 5FU plus leukovorin (LV) has shown reponse rates >40%, in addition, a combination consisting of 5FU plus interferon- α has also obtained response rates >30%.<BR>However.most studies employed these regimens have failed to shown significant prolongation of survival time compared to 5FU alone.<BR>Adjuvant Chemotherapy : A combination consisting of 5FU and levmnizole has recognized to be a standard adjuvant regimen for Dukes C. Recently prospective randomized trials comparing 5FU plus LV versus control reported significant improvement of disease free survival and overall survival in 5FU plus LV arm.<BR>A combination regimen consisting of Methgl CCNU, oncovin and 5FU(MOF) has escalated 3 year survival rate of rectal cancer compared to control or irradiation. Thus this treatment has considered to be the first chonce at present time but confirmatory studies are in progress.

収録刊行物

• 日本大腸肛門病学会雑誌

  日本大腸肛門病学会雑誌 47 (8), 679a-679a,877, 1994

  日本大腸肛門病学会

キーワード

• Gastroenterology
• Surgery

詳細情報

• CRID: 1390001204855933312
• NII論文ID: 130000783921
• DOI: 10.3862/jcoloproctology.47.679a
• ISSN: 18829619
• ISSN: 00471801
• Web Site: http://www.jstage.jst.go.jp/article/jcoloproctology1967/47/8/47_8_679a/_pdf
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