キレート化剤ＤＴＰＡの毒性評価

DOI 被引用文献1件
  • 福田 俊
    放射線医学総合研究所内部被ばく研究部

書誌事項

タイトル別名
  • Assessment of toxicity on chelating agent DTPA(diethylenetriaminepentaacetic Acid).
  • Diethylenetriaminepentaacetic Acid

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抄録

DTPA (diethylenetriaminepentaacetic acid) is a very important chelating agent to decorporate the radionuclides such as plutonium and americium from human body. However, before DTPA will be administered to humans, the toxicity should be clarified.<br>This report described the summary on data of DTPA toxicities obtained from animal experiments and assessment on the safety for humans, based on the results that compared their data among animal species. In short, Ca-DTPA is less toxic than Zn-DTPA when it is injected intravenously, while Zn-DTPA is less toxic than Ca-DTPA when it is administered orally. Both DTPAs acted on the serum calcium metabolism and induced the functional damages of cardiovascular system. Particularly, it is stressed that Zn-DTPA by intravenous injection occurred the heart failure, increases of blood pressure and pulse with hypocalcemia in even normal rats and beagle dogs. Other side effects by both DTPAs were also observed in the intestine, liver, kidney and bone. It is estimated that there are almost no species differences on DTPA toxicity between animals and humans.<br>As a result, it is concluded that DTPA should be used very carefully for humans, with reference to the results obtained from animal experiments.

収録刊行物

  • 保健物理

    保健物理 24 (3), 201-210, 1989

    日本保健物理学会

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