Aldehyde Dehydrogenase 2 (ALDH2) Genotype Affects Rectal Cancer Susceptibility Due to Alcohol Consumption.

• Matsuo Keitaro

  Division of Epidemiology and Prevention,Aichi Cancer Center Research Institute Department of Epidemiology,Nagoya University Graduate School of Medicine

• Hamajima Nobuyuki

  Division of Epidemiology and Prevention,Aichi Cancer Center Research Institute

• Hirai Takashi

  Department of Gastroenterological Surgery,Aichi Cancer Center Hospital

• Kato Tomoyuki

  Department of Gastroenterological Surgery,Aichi Cancer Center Hospital

• Koike Kouichi

  Department of Clinical Laboratory,Aichi Cancer Center Hospital

• Inoue Manami

  Division of Epidemiology and Prevention,Aichi Cancer Center Research Institute

• Takezaki Toshiro

  Division of Epidemiology and Prevention,Aichi Cancer Center Research Institute

• Tajima Kazuo

  Division of Epidemiology and Prevention,Aichi Cancer Center Research Institute

抄録

Background:Epidemiologic studies have shown the association between alcohol consumption and colorectal cancer, especially for rectal cancer.The alcohol related enzyme encoding gene ALDH2 has polymorphism Glu487Lys, and 487Lys allele is closely linked with phenotypic loss of enzyme activity.Materials and Methods:A hospital-based case-control study was conducted with 72 colon and 70 rectal cancer cases and 241 non-cancer controls to evaluate the alcohol consumption and ALDH2 Glu487Lys polymorphism.The logistic regression model was applied to estimate the odds ratios(ORs).Result:The crude ORs for Glu/Lys and Lys/Lys genotype relative to Glu/Glu for colon and rectal cancer were not statistically significant.However, with the rectal cancer analysis, the ORs for high alcohol consumption were greater with 487GIu/Lys genotype compared with Glu/Glu, albeit not.Conclusions:These observations suggested rectal cancer risk might be influenced by ALDH2 gene polymorphism.The prevention effect by alcohol reduction might differ by ALDH2 genotype.J Epidemiol, 2002;12:70-76

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ 12 (2), 70-76, 2002

  日本疫学会

キーワード

• colorectal cancer
• genetic predisposition of disease
• alcohol
• ALDH2 polymorphism

詳細情報

• CRID: 1390282679450396544
• NII論文ID: 130000797515
• NII書誌ID: AA10952696
• DOI: 10.2188/jea.12.70
• COI: 1:STN:280:DC%2BD383ptlCmtg%3D%3D
• ISSN: 13499092
• ISSN: 09175040
• PubMed: 12033531
• Web Site: https://www.jstage.jst.go.jp/article/jea1991/12/2/12_2_70/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003161404
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • PubMed
  • CiNii Articles
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