書誌事項
- タイトル別名
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- A study on the effect of aging on salivary gland and xerostomia.
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抄録
To elucidate the effect of aging on salivary gland, age-related histological changes of parotid gland and age-related changes in the volume of total saliva at rest were evaluated. Histopath- ological investigation of parotid gland and sialometric analysis were also performed in subjects with xerostomia to elucidate the effect of aging on pathogenesis of xerostomia. Decrease in the number of acinus was histopathologically studied in several microscopic fields, and the rate of remaining acinus was evaluated as residual rate. Residual rate of acinus in parotid gland in normal subjects aged 11-40 (N=9) and in those aged 51-80 (N=15) without apparent signs and symptoms of abnormalities of salivary gland were 88.4±7.1% and 67.9±16.9% respectively.<br>Aging caused statistically significant atrophy of parotid parenchym (P⟨0.05). Total saliva at rest in the male and the female subjects aged 11-40 were 3.3±2.5 (N=75) and 3.0±2.1 (N=75) respectively and were 2.8±2.0 (N=75) and 1.6±1.5 (N=75) in the male and the female subjects aged 51-80 respectively. Aging caused significant decrease of the volume of total saliva at rest only in female subjects (P⟨0.05). Apparent sex and age differences were observed in incidence of xerostomia due to atrophy of salivary parenchym which showed significant age-related increase only in female subjects after menopause. Histopathological findings of parotid gland in these patients were characterized by decreased number of acinus with concomitant increase of fat tissue.<br>Residual rate of acinus in parotid gland (N=13) ranged between 28 and 59% (46.2±9.3). Electronmicroscopically fat droplets, lipofuscin granules and vacuoles were occasionally observed in cytoplasm of remaining acinus cells and peripheral duct epithelial cells. However these degenerative changes were generally mild and majority of individual remaining acinus was assumed ultrastructurally to restore normal function. Pathogenesis of xerostomia due to parenchymal atrophy of salivary gland is related closely with the effect of aging not only on salivary gland but also probably on reproductive hormonal system.<br>Incidence of drug-induced xerostomia also showed age-related increase in female subjects. Residual rate of acinus in parotid gland of these patients (N=14) ranged between 18 and 70% (50.4±15.3). Incidence of various systemic diseases which require medications increase with aging. In many patients with drug-induced xerostomia, salivary gland had undergone various degree of age-related parenchymal atrophy. In these subjects mild secretory suppression induced by medication is assumed to result in sufficient decrease of salivary secretion to cause clinical symptoms.
収録刊行物
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- 日本耳鼻咽喉科学会会報
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日本耳鼻咽喉科学会会報 91 (11), 1837-1846, 1988
一般社団法人 日本耳鼻咽喉科頭頸部外科学会