慢性糸球体腎炎における活性化マクロファージ  [in Japanese] Macrophage activation and polarization in chronic glomerulonephritis  [in Japanese]

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Abstract

マクロファージの腎糸球体または尿細管間質への浸潤は,すべての進行性腎疾患にみられる普遍的な現象である。私たちのこれまでの検討から,特にマクロファージの「活性化」は腎障害の発症・進展機序の中で重要な過程であることが明らかになっている。近年,マクロファージの活性化様式には,組織障害にかかわる古典的なM1型と,組織修復や線維化にかかわるM2型の2系統の活性様式があることが知られており,私たちは慢性糸球体腎炎におけるM1,M2浸潤とその役割を検討してきた。本総説では,これまでの検討から得られた知見をもとに慢性糸球体腎炎の進展機序におけるM1,M2活性化マクロファージの機能についてまとめた。

 Macrophage (MQ) infiltration within the glomerular and interstitial compartments is a common feature in most forms of glomerulonephritis (GN). We have studied role of MQs in the pathogenesis of chronic GN in both human and experimental model of GN, and reported that ‘activation’ of MQ is one of the most important processes during the initiation and the progression of chronic GN.<br> During the last decade, it has become clear that macrophages respond to various stimuli to generate phenotypically distinct states of activation. These activation states have been termed ‘classical (pro-inflammatory)’ and ‘alternative’ and represent a range of cellular phenotypes. Pro-inflammatory M1-type MQs (M1) are often associated with tissue damage, whereas alternatively activated M2-type MQs (M2) are usually associated with tissue repair and often involved in fibrosis. Thus, M1 or M2 may explain the underlying differences in pathology of chronic GN. Here we review the main functions of polarized macrophages and discuss the perspectives of this field.

Journal

  • Nihon Shoni Jinzobyo Gakkai Zasshi

    Nihon Shoni Jinzobyo Gakkai Zasshi 23(2), 134-140, 2010

    The Japanese Society for Pediatric Nephrology

Codes

  • NII Article ID (NAID)
    130000814253
  • Text Lang
    JPN
  • ISSN
    0915-2245
  • Data Source
    J-STAGE 
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