Heterogeneity in vasorelaxant effects of .ALPHA.-human atrial natriuretic polypeptide in the dog.

• ISHIKAWA Naohisa

  Department of Pharmacology, Nagoya University School of Medicine

• HAYAKAWA Akemi

  Department of Pharmacology, Nagoya University School of Medicine

• UEMATSU Toshihiko

  Department of Pharmacology, Hamamatsu University School of Medicine

• NAKASHIMA Mitsuyoshi

  Department of Pharmacology, Hamamatsu University School of Medicine

Abstract

Effects of α-human natriuretic polypeptide (ANP) on isolated canine vascular strips were examined in 6 arteries and 5 veins. Under the preconstriction with either methoxamine, prostaglandin F_2α or KCI, ANP relaxed the vascular strips to various degrees, depending on the region removed from the circulatory system. The largest relaxation was obtained in the pulmonary artery, suggesting that the pulmonary artery may be an important site of action of ANP.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 44 (4), 515-518, 1987

  The Japanese Pharmacological Society

Keywords

• Pharmacology

Details

• CRID: 1390282679265295488
• NII Article ID: 130000831964
• DOI: 10.1254/jjp.44.515
• COI: 1:CAS:528:DyaL2sXkvFSrtbk%3D
• ISSN: 13473506
• ISSN: 00215198
• PubMed: 2960841
• Web Site: https://search.jamas.or.jp/link/ui/1988191386
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed