Effects of pantoyl-GABA on GABAA and GABAB receptors in the rat brain.
Access this Article
The interactions of the “antidementia drug” pantoyl-γ-aminobutyric acid (pantoyl-GABA) with γ-aminobutyric acid (GABA) receptors were investigated by studies on bindings of radiolabelled ligands in rat brain. Pantoyl-GABA inhibited the binding of [<SUP>3</SUP>H]GABA to GABA<SUB>A</SUB> receptors and those of [<SUP>3</SUP>H]baclofen and [<SUP>3</SUP>H]GABA to GABA<SUB>B</SUB> receptors in the rat cerebral cortex. These data suggest that pantoyl-GABA interacts with both types of GABA receptors in the rat brain.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 45(2), 292-294, 1987
The Japanese Pharmacological Society