Effects of pantoyl-GABA on GABAA and GABAB receptors in the rat brain.

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Author(s)

    • NISHI Nobuo
    • Department of Pharmacology I, Osaka University School of Medicine
    • MOCHIZUKI Daisuke
    • Division of Pharmacology, Medicinal Research Laboratories, Toyo Jozo Co., Ltd.
    • KATO Susumu
    • Department of Pharmacology I, Osaka University School of Medicine
    • UCHIDA Shuji
    • Department of Pharmacology I, Osaka University School of Medicine

Abstract

The interactions of the “antidementia drug” pantoyl-γ-aminobutyric acid (pantoyl-GABA) with γ-aminobutyric acid (GABA) receptors were investigated by studies on bindings of radiolabelled ligands in rat brain. Pantoyl-GABA inhibited the binding of [<SUP>3</SUP>H]GABA to GABA<SUB>A</SUB> receptors and those of [<SUP>3</SUP>H]baclofen and [<SUP>3</SUP>H]GABA to GABA<SUB>B</SUB> receptors in the rat cerebral cortex. These data suggest that pantoyl-GABA interacts with both types of GABA receptors in the rat brain.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 45(2), 292-294, 1987

    The Japanese Pharmacological Society

Codes

  • NII Article ID (NAID)
    130000832016
  • Text Lang
    ENG
  • ISSN
    0021-5198
  • Data Source
    J-STAGE 
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