Blockade of the development of analgesic tolerance to morphine by concurrent treatment with opioid-but not non-opioid-mediated stress in mice.

DOI PubMed 被引用文献5件
  • TAKAHASHI Masakatsu
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
  • DEGUCHI Yoshiki
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
  • KANETO Hiroshi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

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Studies have been carried out to determine how the analgesic effect of morphine and the development of tolerance to the effect would be influenced by concurrent exposure to stresses in mice. Application of footshock (FS) stress, which produces analgesia mediated by opioid μ-receptors, or psychological (PSY) stress, which produces analgesia in a manner more closely related to opioid κ-receptors, did not affect the analgesic effect of morphine, but completely blocked the development of tolerance during 5 daily concomitant treatments. On the other hand, forced swimming (SW) stress induced analgesia (SIA), which was not antagonized by naloxone, suppressed morphine analgesia, but failed to block the tolerance development. The blockade of the development of tolerance to morphine analgesia by stresses may not be attributed to the analgesic effect induced by the stresses because a combination of weak FS stress, which induces no analgesia, also effectively suppressed the development of morphine tolerance. In addition to the opioid mechanism, an adrenergic mechanism can not be excluded because of the reserpine antagonism of these SIAs.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 46 (1), 1-5, 1988

    公益社団法人 日本薬理学会

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