Effects of repeated administrations of facteur thymique serique(FTS) on biochemical changes related to aging in senescence-accelerated mouse(SAM).

• ZHAO Xue-Hui

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

• AWAYA Akira

  Institute of Biological Sciences, Mitsui Pharmaceuticals, Inc.

• KOBAYASHI Hisashi

  Institute of Biological Sciences, Mitsui Pharmaceuticals, Inc.

• OHNUKI Toshio

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

• TOKUMITSU Yukiko

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

• NOMURA Yasuyuki

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

Bibliographic Information

Other Title

• Effects of Repeated Administrations of Facteur Thymique Sérique (FTS) on Biochemical Changes Related to Aging in Senescence-Accelerated Mouse (SAM)

Abstract

Superoxide dismutase (SOD) activity, malondialdehyde (MDA) content and monoamine oxidase B (MAO-B) activity were measured in the brain, liver and kidney of a normal aging strain (R/1) and an accelerating aging strain (P/8) senescence-accelerated mice (SAM) at 9-10 months of age, and the effects of facteur thymique sérique (FTS) were examined. The activity of Cu, Zn-SOD in the kidney and MAO-B in the liver was significantly low and high in SAM-P/8 compared to SAM-R/1. FTS enhanced the activity of Mn-SOD and Cu, Zn-SOD in the kidney of SAM-P/8 and Cu, Zn-SOD activity in the brain of both SAM-P/8 and SAM-R/1. It decreased the activity of MAO-B in the liver and the contents of malondialdehyde (MDA) in the brain and kidney of SAM-P/8. Thus, FTS affects the biochemical factors related to senescence in SAM-P/8, a particular senescent animal model, and may thus possibly be effective as an anti-senescent medicine.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 53 (3), 311-319, 1990

  The Japanese Pharmacological Society

Keywords

• Pharmacology

Details

• CRID: 1390282679262378368
• NII Article ID: 130000832846
• DOI: 10.1254/jjp.53.311
• COI: 1:CAS:528:DyaK3cXltFemtro%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• PubMed: 1697347
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819520042?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819520042?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1993201706
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed