The anticonflict effect of MK-801, an NMDA antagonist: Investigation by punishment procedure in mice.

• KURIBARA Hisashi

  Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine

• FUJIWARA Suguru

  Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine

• YASUDA Hideko

  Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine

• TADOKORO Sakutaro

  Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine

Abstract

The NMDA antagonist MK-801 at 0.3 mg/kg, i.p. increased the punished response under a MULT VI 1.5/FR 5-punishment schedule of food reinforcement in mice. Furthermore, although neither MK-801 (0.1 mg/kg, i.p.) nor diazepam (0.25 mg/kg, s.c.) was without effect when separately administered, a significant increase in the punished response appeared after the combined administration of these two drugs. The present results suggest that MK-801 not only shows an anticonflict effect, but also enhances the anticonflict effect of benzodiazepine anxiolytics in mice.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 54 (2), 250-252, 1990

  The Japanese Pharmacological Society

Keywords

• Pharmacology

Details

• CRID: 1390282679263462656
• NII Article ID: 130000832937
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.54.250
• COI: 1:CAS:528:DyaK3cXmtVCkt7c%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• PubMed: 2077189
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819327969?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819327969?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1993131388
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed