The Effect of Tacrine (THA) on Cycloheximide- and Basal Forebrain Lesion-Induced Memory Deficit in Rats.
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- Nabeshima Toshitaka
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University Department of Hospital Pharmacy, Nagoya University School of Medicine
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- Maruyama Eiko
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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- Katoh Akira
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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- Kameyama Tsutomu
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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抄録
The effects of 9-amino-1, 2, 3, 4-tetrahydroacridine (tacrine), an active acetylcholinesterase inhibitor, on cycloheximide- and basal forebrain (BF) lesion-induced memory deficit in the water maze and passive avoidance task were investigated. While cycloheximide (1.5 mg/kg, s.c.) produced amnesia in the passive avoidance task, chronic administration of tacrine (1, 3 and 10 mg/kg, once a day for 1 week) improved the amnesia. BF lesion produced amnesia in both the water maze and passive avoidance tasks. Chronic tacrine (0.1-3 mg/kg, passive avoidance task, or 0.3 mg/kg, water maze task, once a day for 1 week) improved BF lesion-induced amnesia in the passive avoidance and water maze tasks. These results suggest that tacrine may be useful for senile dementia.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 57 (3), 311-319, 1991
公益社団法人 日本薬理学会
