Modification of cisplatin toxicity by antioxidants.

• SUGIHARA Kumi

  Department of Pharmacology, Osaka College of Pharmacy

• GEMBA Munekazu

  Department of Pharmacology, Osaka College of Pharmacy

抄録

-cis-Diamminedichloroplatinum II (cisplatin) is a potent anticancer chemotherapeutic agent. The major limitation in its use is nephrotoxicity, caused by an unknown mechanism. Injection of cisplatin into rats caused a decrease in body weight and an increase in blood urea nitrogen (BUN). These effects were modified by giving a radical scavenger, α-tocopherol, before the cisplatin injection. N-N'-diphenyl-p-phenylenediamine, another powerful radical scavenger, also attenuated the increase in BUN induced by cisplatin. These results suggest that the toxic effects of cisplatin may be related to free radical induced damage.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 40 (2), 353-355, 1986

  公益社団法人 日本薬理学会

キーワード

• Pharmacology

詳細情報

• CRID: 1390282679267157632
• NII論文ID: 130000834591
• DOI: 10.1254/jjp.40.353
• COI: 1:CAS:528:DyaL28XotFKktA%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• PubMed: 3702152
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819378965?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819378965?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1987012016
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可