Relaxing action of Trepibutone (AA-149) on the isolated sphincter of oddi and small intestine of rabbits.
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We investigated the smooth muscle relaxing action of trepibutone [3-(2, 4, 5-triethoxybenzoyl)pro pi onic acid: AA-149] using assays of the isolated preparations of sphincter of Oddi, duodenum, jejunum and ileum of rabbits. Trepibutone (10<SUP>-6</SUP>-10<SUP>-3</SUP> M) markedly relaxed the sphincter of Oddi and duodenum, while papaverine (10<SUP>-6</SUP>-10<SUP>-4</SUP>M) exerted an equipotent relaxing activity in all these preparations. The actions of trepibutone were not altered by pretreatment with tetrodotoxin, phentolamine or propranolol. However, trepibutone at a concentration of 3×10<SUP>-3</SUP> M, unlike papaverine, had no effect on the contractile response to ACh. These results indicate that trepibutone relaxes smooth muscle by a direct action which differs from the action of papaverine.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 31(4), 587-592, 1981
The Japanese Pharmacological Society