Relaxing action of Trepibutone (AA-149) on the isolated sphincter of oddi and small intestine of rabbits.

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Author(s)

Abstract

We investigated the smooth muscle relaxing action of trepibutone [3-(2, 4, 5-triethoxybenzoyl)pro pi onic acid: AA-149] using assays of the isolated preparations of sphincter of Oddi, duodenum, jejunum and ileum of rabbits. Trepibutone (10<SUP>-6</SUP>-10<SUP>-3</SUP> M) markedly relaxed the sphincter of Oddi and duodenum, while papaverine (10<SUP>-6</SUP>-10<SUP>-4</SUP>M) exerted an equipotent relaxing activity in all these preparations. The actions of trepibutone were not altered by pretreatment with tetrodotoxin, phentolamine or propranolol. However, trepibutone at a concentration of 3×10<SUP>-3</SUP> M, unlike papaverine, had no effect on the contractile response to ACh. These results indicate that trepibutone relaxes smooth muscle by a direct action which differs from the action of papaverine.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 31(4), 587-592, 1981

    The Japanese Pharmacological Society

Codes

  • NII Article ID (NAID)
    130000835648
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • ISSN
    0021-5198
  • NDL Article ID
    2356934
  • NDL Source Classification
    SD0(薬学)
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    NDL  J-STAGE 
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