DRUG METABOLIZING FUNCTION OF ISOLATED PERFUSED LIVER

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  • NODA Tsutomu
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
  • ARAKI Kazunori
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
  • KOIDA Masao
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
  • KANETO Hiroshi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

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タイトル別名
  • Drug metabolizing function of isolated

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抄録

How closely the isolated liver of the rat would simulate the in vivo function of the organ in terms of the metabolic pattern of the compounds such as bromosulphophthalein, ρ-nitrophenol, hexobarbital, and indocyanine green was investigated. In order to produce tissue with the stimulated function, the animal was pretreated with phenobarbital and, for the reverse purpose, with ethionine. Some of the indices of the function employed herein, such as the appearance pattern of the compound, the rate of biochemical transformation or the biliary excretion, showed that the perfused liver would generally well reflect the in vivo situation. The method with isolated and perfused liver could exclude the participation of other organs and also the influence of the factors unavoidable in an in vivo experiment. Thus, it is suggested that the isolated perfused liver is useful for studying directly the functional level of the organ as drug metabolizing tissue.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 25 (3), 325-333, 1975

    公益社団法人 日本薬理学会

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