The Effect of Nilvadipine, a Dihydropyridine Type Calcium Channel Blocker, on Local Cerebral Blood Flow in Rats.

Furuichi Yasuhisa, Takakura Shoji, Satoh Hisashi, Mori Jo, Kohsaka Masanobu

doi:10.1254/jjp.58.457

The Effect of Nilvadipine, a Dihydropyridine Type Calcium Channel Blocker, on Local Cerebral Blood Flow in Rats.

DOI PubMed 被引用文献5件

Furuichi Yasuhisa

Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Takakura Shoji

Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Satoh Hisashi

Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Mori Jo

Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Kohsaka Masanobu

Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.

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The effect of nilvadipine, a dihydropyridine type calcium channel blocker, on local cerebral blood flow (lCBF) was investigated using the autoradiographic iodo[¹⁴C]antipyrine technique in rats. In control rats, lCBF in cortical areas and in the superior colliculus and inferior colliculus was higher than that in the hippocampus, septal nucleus, globus pallidus and substantia nigra. Nilvadipine (32 μg/kg, i.v.) increased lCBF in all structures (significantly in 11 of 21 structures) in spite of a 33% reduction in mean arterial blood pressure. These results confirm that nilvadipine has the ability to increase cerebral blood flow.